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產(chǎn)品規(guī)格
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BN40667R-100ul
100ul
￥2360.00
交叉反應：Mouse,Rat(predicted:Human,Dog,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,ICC,IF
BN40667R-200ul
200ul
￥3490.00
交叉反應：Mouse,Rat(predicted:Human,Dog,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,ICC,IF
產(chǎn)品描述
| 英文名稱 | E2F3 |
| 中文名稱 | 轉錄因子E2F-3抗體 |
| 別 名 | DKFZp686C18211; E2F 3; E2F transcription factor 3; KIAA0075; MGC104598; Transcription factor E2F 3; E2F3_HUMAN; Transcription factor E2F3; E2F-3. |
| 研究領域 | 免疫學 染色質和核信號 轉錄調節(jié)因子 表觀遺傳學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Dog, Horse, Rabbit, ) |
| 產(chǎn)品應用 | IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human E2F3:91-190/465 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]. Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Subunit: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with TFDP1/Dp-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP. Subcellular Location: Nucleus. Similarity: Belongs to the E2F/DP family. SWISS: O00716 Gene ID: 1871 Database links: Entrez Gene: 1871 Human GenBank: AAH16847 Human Omim: 600427 Human SwissProt: O00716 Human Unigene: 269408 Human Unigene: 703174 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 轉錄調節(jié)因子（Transcriptin Regulators） E2F3轉錄因子具有調控細胞增殖、分化和凋亡相關基因轉錄的重要作用. |
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