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Rho GTP酶激活蛋白26抗體

產品貨號：

BN40292R
中文名稱：

Rho GTP酶激活蛋白26抗體
英文名稱：

Rabbit anti-GRAF Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40292R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB,ELISA
BN40292R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應用：WB,ELISA

產品描述

英文名稱	GRAF
中文名稱	Rho GTP酶激活蛋白26抗體
別名	arhgap 26; ARHGAP26; FLJ42530; GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; oligophrenin 1 like protein; Oligophrenin-1-like protein; oligophrenin1like protein; OPHN1L; OPHN1L1; RHG26_HUMAN; Rho GTPase activating protein 26; Rho GTPase activating protein26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26.
研究領域	腫瘤心血管神經生物學信號轉導細胞骨架細胞外基質 G蛋白信號
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	92kDa
細胞定位	細胞漿細胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GRAF1:1-100/814
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases. Function: GTPase-activating protein for RHOA and CDC42. Subunit: Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1. Subcellular Location: Cell junction; focal adhesion. Cytoplasm; cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures. DISEASE: Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient. Similarity: Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain. SWISS: Q9UNA1 Gene ID: 23092 Database links: Entrez Gene: 23092 Human Entrez Gene: 71302 Mouse Entrez Gene: 307459 Rat Omim: 605370 Human SwissProt: Q9UNA1 Human SwissProt: Q6ZQ82 Mouse Unigene: 654668 Human Unigene: 329396 Mouse Unigene: 214162 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.