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蔗糖非發酵蛋白SNF2H抗體

產品貨號：

BN40384R
中文名稱：

蔗糖非發酵蛋白SNF2H抗體
英文名稱：

Rabbit anti-SNF2H Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40384R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40384R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	SNF2H
中文名稱	蔗糖非發酵蛋白SNF2H抗體
別名	4933427E24Rik; ATP-dependent chromatin remodeling protein SNF2H; D030040M08Rik; D330027N15Rik; EC 3.6.1.-; hISWI; hSNF2H; ISWI; MommeD4; SMARCA5; SMCA5; SMCA5_HUMAN; Snf2h; Sucrose nonfermenting like 5; Sucrose nonfermenting protein 2 homolog; Sucrose nonfermenting, yeast, homolog of; sucrose nonfermenting-like 5; SWI/SNF related matrix associated actin dependent regulator of chromatin a5; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; WCRF135.
研究領域	細胞生物表觀遺傳學
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Guinea Pig, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	122kDa
細胞定位	細胞核
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human SNF2H:901-1000/1052
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008] Function: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed. DISEASE: Developmental stage; Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy. Similarity: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 2 SANT domains. SWISS: O60264 Gene ID: 8476 Database links: Entrez Gene: 8467 Human Entrez Gene: 93762 Mouse Entrez Gene: 307766 Rat Omim: 603375 Human SwissProt: O60264 Human SwissProt: Q91ZW3 Mouse Unigene: 558422 Human Unigene: 246803 Mouse Unigene: 474173 Mouse Unigene: 128772 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.