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BN40399R-100ul
100ul
￥2360.00
交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,ELISA
BN40399R-200ul
200ul
￥3490.00
交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,ELISA
產(chǎn)品描述
| 英文名稱 | ING1 |
| 中文名稱 | 生長(zhǎng)抑制因子基因1抗體 |
| 別 名 | ING1_HUMAN; Inhibitor of growth protein 1; inhibitor of growth gene 1; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds; ING 1; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; p24ING1c; p33 ING1; p33ING1; p33ING1b; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human inhibitor of growth gene 1:301-422/422 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]. Function: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Subcellular Location: Nucleus. Tissue Specificity: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. DISEASE: Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck. Similarity: Belongs to the ING family. Contains 1 PHD-type zinc finger. SWISS: Q9UK53 Gene ID: 3621 Database links: Entrez Gene: 3621 Human Entrez Gene: 26356 Mouse GenBank: NP_937862 Human Omim: 601566 Human SwissProt: Q9UK53 Human SwissProt: Q9QXV3 Mouse Unigene: 46700 Human Unigene: 508725 Human Unigene: 25709 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 腫瘤的發(fā)生是一個(gè)多基因參與,多步驟發(fā)生的復(fù)雜過(guò)程，抑癌基因的功能失活與癌基因的激活為其主要原因之一。 ING1基因是近期發(fā)現(xiàn)的抑癌基因，研究發(fā)現(xiàn)，它的過(guò)表達(dá)可抑制細(xì)胞生長(zhǎng)、增殖,促進(jìn)細(xì)胞凋亡，它的低表達(dá)與腫瘤的發(fā)生、發(fā)展有關(guān)。ING1正常時(shí)定位于胞核，發(fā)揮其誘導(dǎo)凋亡和調(diào)控細(xì)胞周期的作用，當(dāng)其易位于胞質(zhì)時(shí)上述作用逐步減弱或消失，在腫瘤發(fā)生時(shí)，多位于胞漿。 |
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