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富含GC啟動子結合蛋白1/血管壁相連蛋白抗體

產品貨號：

BN40426R
中文名稱：

富含GC啟動子結合蛋白1/血管壁相連蛋白抗體
英文名稱：

Rabbit anti-GPBP1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40426R-100ul

100ul

￥2360.00

交叉反應：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40426R-200ul

200ul

￥3490.00

交叉反應：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱	GPBP1
中文名稱	富含GC啟動子結合蛋白1/血管壁相連蛋白抗體
別名	Vasculin; DKFZp761C169; GC rich promoter binding protein 1; GC-rich promoter-binding protein 1; GPBP; Gpbp1; GPBP1_HUMAN; MGC126339; SSH6; Vascular wall linked; Vascular wall-linked protein.
研究領域	細胞生物轉錄調節因子
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	53kDa
細胞定位	細胞核細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GPBP1/Vasculin:11-110/473
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Vascular wall-linked protein, or Vasculin, is primarily expressed in the arterial wall and in plasma. It is also differentially expressed in human atherogenesis. Alternative splicing of exon 3 of the Vasculin gene produces three variants. Vasculin binds to and activates the minimal self-sufficient promoter element (MSPE) of the mouse Ada gene promoter and binds to and partially suppresses the GC-rich promoter of the nonhomologous human TOP2A gene promoter. It acts as a nuclear factor that can form complexes with TATA-binding proteins, transcription factors TFIIB and TFIIF, RNA polymerase II and p300. The regulated expression of Vasculin in plaques suggests that it may be involved in atherogenesis, and its presence in plasma may implicate Vasculin as a marker for atherosclerosis. Function: Functions as a GC-rich promoter-specific transactivating transcription factor. Subunit: Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP (By similarity). Subcellular Location: Nucleus. Cytoplasm. According to PubMed:12842993, it localizes to the cytoplasm. Tissue Specificity: Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells. Similarity: Belongs to the vasculin family. SWISS: Q86WP2 Gene ID: 65056 Database links: Entrez Gene: 65056 Human Entrez Gene: 73274 Mouse Entrez Gene: 294734 Rat Entrez Gene: 613751 Cow SwissProt: Q0P5K1 Cow SwissProt: Q86WP2 Human SwissProt: Q9H0D4 Human SwissProt: Q9H785 Human SwissProt: Q3TQR2 Mouse SwissProt: Q6NXH3 Mouse SwissProt: Q6TYE7 Mouse SwissProt: Q8R252 Mouse Unigene: 17440 Cow Unigene: 444279 Human Unigene: 441830 Mouse Unigene: 57286 Mouse Unigene: 33325 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.