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    血管緊張素原抗體
    • 產品貨號:
      BN40652R
    • 中文名稱:
      血管緊張素原抗體
    • 英文名稱:
      Rabbit anti-Angiotensinogen Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40652R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse,Rat 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN40652R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Mouse,Rat 推薦應用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產品描述

    英文名稱Angiotensinogen
    中文名稱血管緊張素原抗體
    別    名Angiotenogen; Angiotensinogen; AT; ANGT_HUMNA; Serpin A8.  
    研究領域心血管  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, Rat, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量49kDa
    細胞定位分泌型蛋白 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Angiotensinogen:51-120/485 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Angiotensinogen protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.

    Function:
    Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
    Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
    Angiotensin-3 stimulates aldosterone release.

    Subunit:
    During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.

    Subcellular Location:
    Secreted.

    Tissue Specificity:
    Expressed by the liver and secreted in plasma.

    DISEASE:
    Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.
    Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

    Similarity:
    Belongs to the serpin family.

    SWISS:
    P01019

    Gene ID:
    183

    Database links:

    Entrez Gene: 183 Human

    Entrez Gene: 11606 Mouse

    Entrez Gene: 24179 Rat

    Omim: 106150 Human

    SwissProt: P01019 Human

    SwissProt: P11859 Mouse

    SwissProt: P01015 Rat

    Unigene: 19383 Human

    Unigene: 301626 Mouse

    Unigene: 6319 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    血管緊張素原(Angiotenogen, AT)是一種大分子糖蛋白和α2球蛋白廣泛分布于血液循環、淋巴、腦、腎臟等組織。


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