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    首頁>>免疫學>>一抗>>Ki67蛋白抗體
    Ki67蛋白抗體
    • 產品貨號:
      BN40753R
    • 中文名稱:
      Ki67蛋白抗體
    • 英文名稱:
      Rabbit anti-Ki-67 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產品規格

      售價

      備注

    • BN40753R-100ul

      100ul

      ¥2360.00

      交叉反應:Human,Mouse 推薦應用:WB,ICC,Flow-Cyt,ELISA

    • BN40753R-200ul

      200ul

      ¥3490.00

      交叉反應:Human,Mouse 推薦應用:WB,ICC,Flow-Cyt,ELISA

    產品描述

    英文名稱Ki-67
    中文名稱Ki67蛋白抗體
    別    名Antigen identified by monoclonal antibody Ki 67; Antigen KI67; KIA; Ki67; MKI67; Proliferation related Ki 67 antigen; Antigen KI-67; KI67_HUMAN.  
    研究領域腫瘤  細胞生物  神經生物學  細胞周期蛋白  細胞分化  細胞類型標志物  表觀遺傳學  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應Human, Mouse, 
    產品應用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/test ICC=1:100 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量358kDa
    細胞定位細胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Ki-67:2901-3000/3256 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產品介紹Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

    Function:
    Thought to be required for maintaining cell proliferation.

    Subcellular Location:
    Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

    Similarity:
    Contains 1 FHA domain.

    SWISS:
    P46013

    Gene ID:
    4288

    Database links:

    Entrez Gene: 4288 Human

    Entrez Gene: 17345 Mouse

    Entrez Gene: 246042 Rat

    Omim: 176741 Human

    SwissProt: P46013 Human

    SwissProt: Q91VE6 Mouse

    SwissProt: Q5RJM0 Rat

    Unigene: 689823 Human

    Unigene: 80976 Human

    Unigene: 4078 Mouse

    Unigene: 233802 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    細胞增殖標志物(Proliferation Marker)
    Ki67與PCNA一樣,為細胞增殖的一種標記,在細胞凋亡中S、G2 、M期均有表達,G0期缺如。 Ki-67增殖指數高低與許多腫瘤的分化程度、浸潤、轉移以及預后密切相關,因此被廣泛作為各種惡性腫瘤的必檢項目之一。


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