最近搜索:細胞培養(yǎng) 微生物學 分子生物 生物化學
    首頁>>免疫學>>一抗>>細胞質(zhì)膜微囊蛋白-1抗體
    細胞質(zhì)膜微囊蛋白-1抗體
    • 產(chǎn)品貨號:
      BN40760R
    • 中文名稱:
      細胞質(zhì)膜微囊蛋白-1抗體
    • 英文名稱:
      Rabbit anti-Caveolin-1 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號

      產(chǎn)品規(guī)格

      售價

      備注

    • BN40760R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用:WB

    • BN40760R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用:WB

    產(chǎn)品描述

    英文名稱Caveolin-1
    中文名稱細胞質(zhì)膜微囊蛋白-1抗體
    別    名opamine D3 receptor; Caveolin1; Caveolin 1; 3 dopamine receptor; D; Dopamine receptor D3; DRD; ETM1; FET1; Cav-1; ETM1; CAV 1; CAV1; CAV1_HUMAN.  
    研究領(lǐng)域信號轉(zhuǎn)導  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
    抗體來源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
    產(chǎn)品應(yīng)用WB=1:500-2000 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量20kDa
    細胞定位細胞漿 細胞膜 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Caveolin-1:2-80/178 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq].

    Function:
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

    Subunit:
    Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK.

    Subcellular Location:
    Golgi apparatus membrane;Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

    Tissue Specificity:
    Expressed in muscle and lung, less so in liver, brain and kidney.

    Post-translational modifications:
    The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
    Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.

    DISEASE:
    Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

    Similarity:
    Belongs to the caveolin family.

    SWISS:
    Q03135

    Gene ID:
    857

    Database links:

    Entrez Gene: 403980 Dog

    Entrez Gene: 857 Human

    Entrez Gene: 12389 Mouse

    Entrez Gene: 25404 Rat

    Omim: 601047 Human

    SwissProt: P33724 Dog

    SwissProt: Q03135 Human

    SwissProt: P49817 Mouse

    SwissProt: P41350 Rat

    Unigene: 3850 Dog

    Unigene: 74034 Human

    Unigene: 28278 Mouse

    Unigene: 470537 Mouse

    Unigene: 22518 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    信號傳導(Signaling Intermediates)
    Caveolin-1(小凹蛋白)是細胞生長相關(guān)信號途徑及腫瘤發(fā)生發(fā)展過程中重要的抑制因子,Caveolae是細胞膜內(nèi)的特殊膜結(jié)構(gòu),參與包括細胞的分子運輸、細胞粘附和信號轉(zhuǎn)導在內(nèi)的多種細胞活動。Caveolin-1是Caveolae中重要的結(jié)構(gòu)蛋白,抑制細胞生長,與多種人類腫瘤發(fā)生發(fā)展相關(guān)的信號分子相互作用。Caveolin在信號轉(zhuǎn)導的整合中起支架蛋白的作用。Caveolin構(gòu)成了一個蛋白家族,他們是細胞質(zhì)膜中發(fā)夾樣結(jié)構(gòu)域的主要結(jié)構(gòu)成分。Caveolin在信號轉(zhuǎn)導的整合中起支架蛋白的作用。至今已經(jīng)鑒定了3種Caveolin (Caveolin-1、2 和3),它們具有不同的組織分布。Caveolin-1涉及乳腺上皮細胞增生的發(fā)病機制。該抗體可識別α和β型Caveolin-1。


























    image.png

    亚洲精品免费在线| 亚洲欧洲日产国码一级毛片| 在线观看免费亚洲| 亚洲综合一区二区三区四区五区| 亚洲六月丁香六月婷婷色伊人| 久久久久久久亚洲Av无码| 亚洲AV永久精品爱情岛论坛| 亚洲精品无码乱码成人| 亚洲精品无码久久久久| 亚洲精品美女久久777777| 亚洲人成人网站色www| 国产国拍精品亚洲AV片| 亚洲人成影院在线无码按摩店| 亚洲乱色熟女一区二区三区丝袜| 中文字幕精品亚洲无线码二区| 在线观看国产区亚洲一区成人| 亚洲人成人一区二区三区| 久久精品九九亚洲精品天堂| 亚洲AV永久无码精品成人| 亚洲一区影音先锋色资源| 亚洲综合激情六月婷婷在线观看| 亚洲色图古典武侠| 亚洲一区精品视频在线| 亚洲AV日韩综合一区尤物| 亚洲乱码无人区卡1卡2卡3| 亚洲6080yy久久无码产自国产| 亚洲av无码成人精品区一本二本| 亚洲a∨无码一区二区| 亚洲成aⅴ人片久青草影院| 亚洲中文字幕视频国产| 亚洲精品色午夜无码专区日韩| 亚洲动漫精品无码av天堂| 亚洲最大福利视频网站| 亚洲伊人久久大香线蕉在观| 亚洲字幕AV一区二区三区四区| 亚洲精品GV天堂无码男同| 国产成人久久精品亚洲小说| 国产精品亚洲视频| 亚洲成在人线av| 亚洲另类图片另类电影| 亚洲日韩AV一区二区三区四区|