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半胱氨酸蛋白酶抗體

產(chǎn)品貨號：

BN40978R
中文名稱：

半胱氨酸蛋白酶抗體
英文名稱：

Rabbit anti-Legumain Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN40978R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Cow,Horse) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA
BN40978R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Cow,Horse) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱	Legumain
中文名稱	半胱氨酸蛋白酶抗體
別名	AEP; Asparaginyl endopeptidase; EC 3.4.22.34; LGMN; LGMN1; Protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1; LGMN_HUMAN.
研究領(lǐng)域	腫瘤細胞生物免疫學細胞凋亡激酶和磷酸酶
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Dog, Cow, Horse, )
產(chǎn)品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=3ug/Test （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	46kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Legumain:201-300/433
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]. Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Subcellular Location: Lysosome (By similarity). Tissue Specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta. Post-translational modifications: Glycosylated. Similarity: Belongs to the peptidase C13 family. SWISS: Q99538 Gene ID: 5641 Database links: Entrez Gene: 5641 Human Entrez Gene: 19141 Mouse Entrez Gene: 63865 Rat Omim: 602620 Human SwissProt: Q99538 Human SwissProt: O89017 Mouse SwissProt: Q9R0J8 Rat Unigene: 726036 Human Unigene: 17185 Mouse Unigene: 206021 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.