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產品規格
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BN40978R-100ul
100ul
￥2360.00
交叉反應：Human,Mouse,Rat(predicted:Dog,Cow,Horse) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA
BN40978R-200ul
200ul
￥3490.00
交叉反應：Human,Mouse,Rat(predicted:Dog,Cow,Horse) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA
產品描述
| 英文名稱 | Legumain |
| 中文名稱 | 半胱氨酸蛋白酶抗體 |
| 別 名 | AEP; Asparaginyl endopeptidase; EC 3.4.22.34; LGMN; LGMN1; Protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1; LGMN_HUMAN. |
| 研究領域 | 腫瘤 細胞生物 免疫學 細胞凋亡 激酶和磷酸酶 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Mouse, Rat, (predicted: Dog, Cow, Horse, ) |
| 產品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=3ug/Test （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Legumain:201-300/433 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]. Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Subcellular Location: Lysosome (By similarity). Tissue Specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta. Post-translational modifications: Glycosylated. Similarity: Belongs to the peptidase C13 family. SWISS: Q99538 Gene ID: 5641 Database links: Entrez Gene: 5641 Human Entrez Gene: 19141 Mouse Omim: 602620 Human SwissProt: Q99538 Human SwissProt: O89017 Mouse Unigene: 726036 Human Unigene: 17185 Mouse Unigene: 206021 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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