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神經肽Y抗體

產品貨號：

BN41478R
中文名稱：

神經肽Y抗體
英文名稱：

Rabbit anti-Neuropeptide Y Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41478R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat(predicted:Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41478R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41478R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	Neuropeptide Y
中文名稱	神經肽Y抗體
別名	Neuropeptide tyrosine; Neuropeptide Y precursor; NPY; PYY 4; PYY4; Y Neuropeptide; Pro-neuropeptide Y; NPY_HUMAN.

研究領域	心血管信號轉導
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Cow, Horse, Rabbit, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	4/8kDa
細胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human NPY:29-64/97
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Subcellular Location: Secreted. Tissue Specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. Post-translational modifications: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Similarity: Belongs to the NPY family. SWISS: P01303 Gene ID: 4852 Database links: Entrez Gene: 396464 Chicken Entrez Gene: 504216 Cow Entrez Gene: 4852 Human Entrez Gene: 109648 Mouse Entrez Gene: 397304 Pig Entrez Gene: 24604 Rat Omim: 162640 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神經生物學相關蛋白神經肽Y是一種神經傳導因子，參與機體的應急反應，在應激狀態下-NPY升高;他還可以促進血小板聚集、白細胞粘附及巨噬細胞活化而參與免疫反應神經肽Y廣泛分布于動物中樞和外周神經元及機體組織、器官和腺體內 ,影響動物采食、激素分泌、心血管效應、調節體溫、生物節律、性行為及動物情緒等多種功能。由于結構中富含酪氨酸 ,故稱為神經肽酪氨酸 (NPY)。它的結構與同是 36個氨基酸的胰多肽 (pp)和肽 YY(PYY)極其相似 ,故認為同屬胰多肽家族。從分子結構看 ,人、大鼠、豚鼠和兔序列安全一致 ,而牛、羊、豬 NPY序列與人的序列只相差一個氨基酸。