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    胚胎干細(xì)胞關(guān)鍵蛋白抗體
    • 產(chǎn)品貨號(hào):
      BN41594R
    • 中文名稱:
      胚胎干細(xì)胞關(guān)鍵蛋白抗體
    • 英文名稱:
      Rabbit anti-Oct4 Polyclonal antibody
    • 品牌:
      Biorigin
    • 貨號(hào)

      產(chǎn)品規(guī)格

      售價(jià)

      備注

    • BN41594R-50ul

      50ul

      ¥1486.00

      交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41594R-100ul

      100ul

      ¥2360.00

      交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    • BN41594R-200ul

      200ul

      ¥3490.00

      交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

    產(chǎn)品描述

    英文名稱Oct4
    中文名稱胚胎干細(xì)胞關(guān)鍵蛋白抗體
    別    名MGC22487; Oct 3; Oct 4; Oct-3; Oct-4; OCT3; Oct4; Octamer binding protein 3; Octamer-binding protein 3; Octamer binding protein 4; Octamer binding transcription factor 3; Octamer-binding transcription factor 3; Octamer-4; POU domain transcription factor OCT4; OTF3; OTF4; OTF 3; OTF 4; OTF-3; POU class 5 homeobox 1; POU domain, class 5, transcription factor 1; POU domain class 5 transcription factor 1; PO5F1_HUMAN; POU type homeodomain containing DNA binding protein ; POU5F1.  




    研究領(lǐng)域細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞類型標(biāo)志物  表觀遺傳學(xué)  
    抗體來(lái)源Rabbit
    克隆類型Polyclonal
    交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, )
    產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 (石蠟切片需做抗原修復(fù))
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量39kDa
    細(xì)胞定位細(xì)胞核 
    性    狀Liquid
    濃    度1mg/ml
    免 疫 原KLH conjugated synthetic peptide derived from human Octamer4:201-300/360 
    亞    型IgG
    純化方法affinity purified by Protein A
    儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMedPubMed
    產(chǎn)品介紹Expression of the POU-domain transcription factor Octamer-4 (Oct-4) is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state.

    Function:
    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

    Subunit:
    Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2.

    Subcellular Location:
    Nucleus.Note=Expressed in a diffuse and slightly punctuate pattern.

    Tissue Specificity:
    Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

    Post-translational modifications:
    Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression (By similarity).
    Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation (By similarity).
    ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription.

    Similarity:
    Belongs to the POU transcription factor family. Class-5 subfamily.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 POU-specific domain.

    SWISS:
    Q01860

    Gene ID:
    5460

    Database links:

    Entrez Gene: 282316 Cow

    Entrez Gene: 5460 Human

    Entrez Gene: 18999 Mouse

    Entrez Gene: 100127461 Pig

    Entrez Gene: 294562 Rat

    Omim: 164177 Human

    SwissProt: O97552 Cow

    SwissProt: Q01860 Human

    SwissProt: P20263 Mouse

    SwissProt: Q9TSV5 Pig

    Unigene: 249184 Human

    Unigene: 632482 Human

    Unigene: 646545 Human

    Unigene: 17031 Mouse

    Unigene: 161748 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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