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生長分化因子9抗體

產品貨號：

BN41911R
中文名稱：

生長分化因子9抗體
英文名稱：

Rabbit anti-GDF9 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN41911R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA
BN41911R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA
BN41911R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA

產品描述

英文名稱	GDF9
中文名稱	生長分化因子9抗體
別名	GDF9_HUMAN; GDF9; GDF-9; GDF 9; Growth differentiation factor 9.
研究領域	心血管免疫學信號轉導干細胞生長因子和激素細胞分化
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	15kDa
細胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GDF9:301-400/454
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	GDF 9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell synthesized by ovarian somatic cells directly affect oocyte growth and function. GDF 9 is expressed in oocytes and is thought to be required for ovarian folliculogenesis. Function: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. Subunit: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity). Subcellular Location: Secreted (By similarity). Tissue Specificity: Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level). Post-translational modifications: Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325. DISEASE: Note=Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins. Similarity: Belongs to the TGF-beta family. SWISS: O60383 Gene ID: 2661 Database links: Entrez Gene: 2661 Human Entrez Gene: 14566 Mouse Entrez Gene: 59304 Rat Omim: 601918 Human SwissProt: O60383 Human SwissProt: Q07105 Mouse Unigene: 25022 Human Unigene: 490461 Mouse Unigene: 9714 Mouse Unigene: 42874 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GDF9屬于轉移生長因子–β(TGF-β)及骨形態發生蛋白（BMP）家族成員。