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周期素E重組兔單克隆抗體

產(chǎn)品貨號(hào)：

BN42072R
中文名稱：

周期素E重組兔單克隆抗體
英文名稱：

Rabbit anti-Cyclin E1 Monoclonal antibody
品牌：

Biorigin

貨號(hào)

產(chǎn)品規(guī)格

售價(jià)

備注
BN42072R-50ul

50ul

￥2020.00

交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,ICC
BN42072R-100ul

100ul

￥3240.00

交叉反應(yīng)：Human,Mouse 推薦應(yīng)用：WB,IHC-P,ICC

產(chǎn)品描述

英文名稱	Cyclin E1
中文名稱	周期素E重組兔單克隆抗體
別名	CCNE 1; CCNE; CCNE1; Cyclin Es; Cyclin Et; CyclinE; G1/S specific cyclin E; G1/S-specific cyclin-E1; CCNE1_HUMAN; pCCNE1.
研究領(lǐng)域	細(xì)胞生物細(xì)胞周期蛋白
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號(hào)	4H7
交叉反應(yīng)	Human, Mouse,
產(chǎn)品應(yīng)用	WB=1:500-2000 IHC-P=1:100-500 ICC=1:50 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	45kDa
細(xì)胞定位	細(xì)胞核
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human Cyclin E1 protein(100-200aa):
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016] Function: Essential for the control of the cell cycle at the G1/S (start) transition. Subunit: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. Post-translational modifications: Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the cyclin family. Cyclin E subfamily. SWISS: P24864 Gene ID: 898 Database links: Entrez Gene: 898 Human Entrez Gene: 12447 Mouse Entrez Gene: 25729 Rat Omim: 123837 Human SwissProt: P24864 Human SwissProt: Q61457 Mouse SwissProt: P39949 Rat Unigene: 244723 Human Unigene: 16110 Mouse Unigene: 15455 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.