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自噬微管相關(guān)蛋白輕鏈3抗體

產(chǎn)品貨號：

BN42205R
中文名稱：

自噬微管相關(guān)蛋白輕鏈3抗體
英文名稱：

Rabbit anti-LC3 Polyclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42205R-50ul

50ul

￥1486.00

交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Sheep,Goat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN42205R-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Sheep,Goat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN42205R-200ul

200ul

￥3490.00

交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Sheep,Goat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱	LC3
中文名稱	自噬微管相關(guān)蛋白輕鏈3抗體
別名	Autophagy related protein LC3 A; Autophagy related protein LC3 B; Autophagy related ubiquitin like modifier LC3 A; Autophagy related ubiquitin like modifier LC3 B; MAP1 light chain 3 like protein 1; MAP1 light chain 3 like protein 2; MAP1A/1B light chain 3 A; MAP1A/1B light chain 3 B; MAP1A/1BLC3; MAP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B; MAP1ALC3; MAP1BLC3; MAP1LC3A; MAP1LC3B; Microtubule associated protein 1 light chain 3 alpha; Microtubule associated protein 1 light chain 3 beta; Microtubule associated proteins 1A/1B light chain 3; Microtubule associated proteins 1A/1B light chain 3A; Microtubule associated proteins 1A/1B light chain 3B; MLP3A_HUMAN.

研究領(lǐng)域	腫瘤細胞生物神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細胞骨架細胞外基質(zhì) 細胞自噬
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應(yīng)	Human, Rat, (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, Goat, )
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	14/16kDa
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human LC3:31-121/121
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with SQSTM1. Interacts with TP53INP1 and TP53INP2. Subcellular Location: Cytoplasmic. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note: LC3B binds to the autophagic membranes. Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Post-translational modifications: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Similarity: Belongs to the MAP1 LC3 family. SWISS: Q9H492 Gene ID: 84557 Database links: Entrez Gene: 84557 Human Entrez Gene: 66734 Mouse Entrez Gene: 362245 Rat Omim: 601242 Human SwissProt: Q9H492 Human SwissProt: Q91VR7 Mouse SwissProt: Q6XVN8 Rat Unigene: 632273 Human Unigene: 196239 Mouse Unigene: 3135 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.